Description

Ancestral sequence reconstruction is a technique of growing importance in molecular biology and comparative genomics. As a powerful technique for both testing evolutionary and ecological hypotheses as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a number of fields. Beginning with a historical overview of the field including apllications, the discussion then moves into potential applications in drug discovery and the pharmaceutical industry. A section on computational methodology provides a detailed discussion on available methods for reconstructing ancestral sequences, including advantages,disadvantages, and potential pitfalls. Purely computational applications, including whole proteome reconstruction are discussed. Another section provides a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory, while the last section describes scientific questions where experimental ancestral sequence reconstruction coupled to a computaional and experimental how-to guide, while simultaneously addressing some of the hot topics in the field.

Features

• Edited by a world-renowned specialist in the field with contributions from an international panel of experts
• The first book to cover the new and expanding discipline of ancestral sequence recognition
• Includes examples of practical applications of this technique, alongside the theoretical and experimental detail
• Ideal graduate seminar course material

Product Details

272 pages; 65 line illus.; 7-1/2 x 9-1/4; ISBN13: 978-0-19-929918-8ISBN10: 0-19-929918-8

About the Author(s)