Combinatorial Chemistry
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Description
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, particularly in pharmaceuticals. This informative text explains the origins of combinatorial chemistry and provides a context for the many diverse library methods. It explains why some techniques are generally applicable while others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. The first single-author book on this growing field, it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimization of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for students and academic and industrial researchers in chemistry, bio-organic chemistry, medicinal chemistry, and pharmaceuticals. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.Reviews
"Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals."--Choice
About the Author(s)
Nicholas K. Terrett, Section Head of New Leads Chemistry, Pfizer Central Research, Kent
